(informal)it is the end or there is no hope for (someone or something)
(非正式)對(duì)…，一切都完了
(Brit.)steadily improving or becoming more successful
(英)穩(wěn)步提高
(chiefly N. Amer.)honest or sincere
(主北美)誠實(shí)的，正直的
(informal)something unusual or undesirable is happening or afoot
(非正式)不尋常（或不好）的事發(fā)生了
(informal)facing some serious but unspecified difficulty
(非正式)面對(duì)某種困難，面臨某種困境
they play better when they're up against it.
面對(duì)困難時(shí)，他們打得更好。
no longer in bed (after sleep or an illness)
（睡眠或生病后） 起床；下床
active; busy
忙碌的，積極肯干的
a normal young chap wants to be up and doing.
正常的年輕人總想積極向上。
moving upwards and downwards
一上一下，起伏
bouncing up and down.
上下跳動(dòng)。
to and fro
來來回回，往返地
pacing up and down in front of her desk.
在她書桌前踱來踱去。
in various places throughout
到處，處處
in clubs up and down the country.
在全國各地俱樂部。
(informal)in varying states or moods; changeable
(非正式)（情緒，狀態(tài)）多變的
my relationship with her was up and down.
我和她的關(guān)系變化不定。
(especially of a computer system) in operation; functioning
（尤指計(jì)算機(jī)系統(tǒng)）運(yùn)行中
the new computer is up and running.
新電腦在運(yùn)行。
the new computer is up and running.
新電腦在運(yùn)行。
appearing for a hearing in the presence of
出庭面對(duì)
we'll have to come up before a magistrate.
我們將不得不出庭面對(duì)治安法官。
available for
正待
the house next door is up for sale.
隔壁房子正待出售。
being considered for
被考慮
he had been up for promotion.
他被考慮提升。
due for
到期
his contract is up for renewal in June.
他的合同將在六月到期續(xù)簽。
(informal)ready to take part in (a particular activity)
(非正式)準(zhǔn)備參加
Nigel was really &B{up for it}, as always.
像平常一樣，奈吉爾真準(zhǔn)備好參加了。
all over the place
到處
he led me up hill and down dale till my feet were dropping off.
他領(lǐng)著我到處走，直到我的腿都快斷了。
(Brit. informal)in the brain (with reference to intelligence)
(英，非正式)頭腦里（指智力）
a man with nothing much up top.
大腦空空的人。